![]() Further aims were to assess the impact of 5-MeO-DMT on cognitive functioning, mood, and well-being. ![]() The psychedelic experience was assessed with a novel Peak Experience Scale (PES), the Mystical Experience Questionnaire (MEQ), the Ego Dissolution Inventory (EDI), the Challenging Experience Questionnaire (CEQ), and the 5-Dimensional Altered States of Consciousness Questionnaire (5D-ASC). In preparation for a study in patients with depression, the present study GH001-HV-101 aimed to assess the impact of four different dose levels of a novel vaporized 5-MeO-DMT formulation (GH001) administered via inhalation as single doses of 2 ( N = 4), 6 ( N = 6), 12 ( N = 4) and 18 mg ( N = 4), and in an individualized dose escalation regimen ( N = 4) on the safety, tolerability, and the dose-related psychoactive effects in healthy volunteers ( N = 22). ![]() Prospective studies for other tryptamines have suggested beneficial effects on mental health outcomes. 2Institute of Legal Medicine, University of Frankfurt, Frankfurt, Germanyĥ-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects.1Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.
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